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Linkage studies in X-linked Alport's syndrome |
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| Authors: | S. Szpiro-Tapia G. Bobrie M. Guilloud-Bataille S. Heuertz C. Julier J. Frézal J. P. Grünfeld M. C. Hors-Cayla |
| Affiliation: | (1) Unité de Recherches de Génétique Médicale, INSERM U. 12, Hôpital des Enfants Malades, 149 Rue de Sèvres, F-75743 Paris Cédex 15, France;(2) Département de Néphrologie, Hôpital Necker, 149, Rue de Sèvres, F-75743 Paris Cédex 15, France;(3) Unité de Recherches de Génétique Epidémiologique, INSERM U. 155, Château de Longchamp, Bois de Boulogne, F-75016 Paris, France;(4) Unité de Recherches en Génétique Moléculaire et en Hématologie, INSERM U. 91, CHU H. Mondor, F-94010 Créteil Cédex, France;(5) Present address: Howard Hughes Medical Institute, University of Utah Medical Center, Wintrobe Building, 84132 Salt Lake City, UT, USA |
| Abstract: | Summary Four kindreds segregating for Alport's syndrome (ASLN) compatible with a X-linked inheritance were studied for linkage with polymorphic markers of the human X chromosome. No recombinant was observed between the ASLN locus and the DXS101 and DXS94 loci, the maximum lod scores were z=3.93 and 3.50 respectively. Linkage data between the ASLN locus and the other genetic markers used in the present study are in keeping with the assignment of the mutation to the proximal Xq arm. |
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