B-raf, a new member of the raf family, is activated by DNA rearrangement. |
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| Authors: | S Ikawa M Fukui Y Ueyama N Tamaoki T Yamamoto and K Toyoshima |
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| Institution: | Department of Oncology, University of Tokyo, Japan. |
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| Abstract: | Complementary DNA clones of a putative transforming gene were isolated from NIH 3T3 cells transformed with human Ewing sarcoma DNA. The gene was termed B-raf because it is related to but distinct from c-raf and A-raf. It appears that substitution in the amino-terminal portion of the normal B-raf protein confers transforming activity to the gene. |
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