Antibacterial activity and mode of action of plant flavonoids against Proteus vulgaris and Staphylococcus aureus |
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| Institution: | 2. Mitsubishi-Kasei Institute of Life Sciences 1,1 Minamiooya, Machida-shi, Tokyo 194, Japan;1. Department of Agricultural Chemistry, University of the Ryukyus, Nishihara-cho, Okinawa 903-01, Japan;1. Clinical Biochemistry Unit, Department of Pathology, College of Medicine, King Saud University, Riyadh 11461, Saudi Arabia;2. Dr. Panjwani Center for Molecular Medicine & Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75210, Pakistan;3. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Turkey;4. Department of Pharmacognosy, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Turkey;5. Faculty of Pharmacy, Eastern Mediterranean University, via Mersin 10, Famagusta 99628, N. Cyprus, Turkey;6. Biomedical Research Laboratory, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia;1. Department of Food Science and Nutrition, College of Food and Agriculture Sciences, King Saud University, Riyadh 11451, Saudi Arabia;2. Department of Botany and Microbiology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia;3. Department of Agricultural Microbiology, Aligarh Muslim University, Aligarh, India;1. Laboratório de Genética de Microrganismos, Departamento de Biologia Molecular, Universidade Federal da Paraíba, João Pessoa, Paraíba, Brazil;2. Laboratório de Processos Microbianos em Alimentos, Departamento de Engenharia de Alimentos, Universidade Federal da Paraíba, João Pessoa, Paraíba, Brazil;3. Laboratório de Microbiologia de Alimentos, Departamento de Nutrição, Universidade Federal da Paraíba, João Pessoa, Paraíba, Brazil |
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| Abstract: | (−)-Epigallocatechin, an antibiotic found in Elaeagnus glabra, and 28 other related plant flavonoids were tested for their antibacterial activity against Proteus vulgaris and Staphylococcus aureus. A free 3′,4′,5′-trihydroxy B-ring and a free 3-OH were necessary for antibacterial activity. DNA synthesis was predominantly inhibited by the active flavonoids in P. vulgaris, whereas RNA synthesis was inhibited in S. aureus. |
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