Neolignans from stem bark of ocotea veraguensis |
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| Institution: | 1. Organic & Biomolecular Chemistry Division, CSIR—Indian Institute of Chemical Technology, Hyderabad 500 607, India;2. Division of Natural Products Chemistry, CSIR—Indian Institute of Chemical Technology, Hyderabad 500 607, India;1. FP-ENAS-Faculdade de Ciências de Saúde, Escola Superior de Saúde da UFP, Universidade Fernando Pessoa, Rua Carlos da Maia, 296, P-4200-150, Porto, Portugal;2. REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências da Universidade do Porto, Rua do Campo Alegre, 687, P-4169-007, Porto, Portugal;3. Department of Chemistry, University of Aberdeen, Meston Walk, Old Aberdeen, AB24 3UE, Scotland, UK;4. Instituto de Tecnologia em Fármacos e Farmanguinhos, Fundação Oswaldo Cruz, 21041-250, Rio de Janeiro, RJ, Brazil;1. Laboratory of Pharmacognosy, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu 501-1196, Japan;2. Gifu Prefectural Research Institute for Health and Environmental Sciences, Naka-fudogaoka, Kakamigahara, Gifu 504-0838, Japan;3. Institute of Microbial Chemistry, 3-14-23 Kamiosaki, Shinagawa-ku, Tokyo 141-0021, Japan;1. Research Group in Pharmaceutical Technology, Postgraduate Program in Heath Science, University of Southern Santa Catarina (UNISUL), Tubarão, Santa Catarina, Brazil;2. Laboratory of Experimental Neuroscience (LANEX), University of Southern Catarina (UNISUL), Palhoça, Santa Catarina, Brazil;1. Institute of Environmental, Chemical and Pharmaceutical Sciences, Federal University of São Paulo, 09972-270, Diadema, SP, Brazil;2. Center of Natural Sciences and Humanities, Federal University of ABC, 09210-580, Santo Andre, SP, Brazil;3. Biotechnology and Innovation in Health Program, Anhanguera University of São Paulo, São Paulo, SP, 05145-200, Brazil;4. School of Engineering, Mackenzie Presbyterian University, 01302-907, São Paulo, SP, Brazil;5. Department of Botany, Institute of Biosciences, University of São Paulo, 05508-090, São Paulo, SP, Brazil;6. Maua Institute of Technology, 09580-900, São Caetano do Sul, SP, Brazil |
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| Abstract: | The stem bark of Ocotea veraguensis has yielded nine neolignans of which five appear to be novel. The new neolignans, which were identified on the basis of spectral characteristics, are* (7S,8R,1′S,2′S,3′R,4′S)-Δ8′-2′,4′-dihydroxy-3,3′5′-trimethoxy-4,5-methylenedioxy-1′,2′,3′,4′-tetrahydro-7.3′,8.1′-neolignan, (7S,8R,1′S,3′S,4′S)-Δ8′-4,4'-dihydroxy-3,3′,5′-trimethoxy-1′,2′,3′,4′-tetrahydro-2′-oxo-7.3′,8.1′-neolignan, (7S,8S,1′R)-Δ8′-3′,5′-dimethoxy-3,4-methylenedioxy-1′,4′-dihydro-4′-oxo-7.0.2′,8.1′-neolignan, (7S,8S,1′R )-Δ8′-1′-methoxy-3,4-methylenedioxy-1′,6′-dihydro-6′-oxo-7.0.4′,8.3′-neolignan and (7S,8S)-Δ8′-2′,6′-dimethoxy-3,4-methylenedioxy-7.0.3′,8.4′,1′.0.7′-neolignan. |
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