Ganoderic acid derivatives and ergosta-4,7,22-triene-3,6-dione from Ganoderma lucidum |
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| Affiliation: | 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People''s Republic of China;2. Graduate University of the Chinese Academy of Sciences, Beijing 100049, People''s Republic of China;1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China;2. Guangdong Key Laboratory for Genome Stability & Disease Prevention, School of Pharmaceutical Sciences, Shenzhen University Health Science Center, Shenzhen 518060, PR China;3. University of Chinese Academy of Sciences, Beijing 100049, PR China;4. The Brain Cognition and Brain Disease Institute, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, PR China;1. Southwest Medical University, Luzhou 646000, PR China;2. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China;3. Guangdong Pharmaceutical University, Guangzhou 5100069, PR China;4. University of Chinese Academy of Sciences, Yuquan Road 19, Beijing 100049, PR China;1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, PR China;2. Central Laboratory, The No. 1 Affiliated Hospital of Yunnan University of Traditional Chinese Medicine, Kunming 650021, PR China;3. Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, and State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, Yunnan University, Kunming 650091, PR China;4. University of Chinese Academy of Sciences, Beijing 100049, PR China |
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| Abstract: | Seven new triterpenoids, ganoderic acid T, ganoderic acid S, ganoderic acid R, ganoderic acid P, ganoderic acid Q, ganoderic acid 0, 7-O-methyl-ganoderic acid 0 and a known ergosterol derivative, ergosta-4,7,22-triene-3,6-dione were isolated from the cultured mycelium of Ganoderma lucidum. The structure of the first compound was determined using spectroscopic and X-ray analysis, and the structures of the other compounds were elucidated by spectroscopic data. |
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