Minor alkaloids of Tylophora hirsuta |
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Institution: | 1. Key Laboratory of Freshwater Animal Breeding, Ministry of Agriculture, College of Fisheries, Huazhong Agricultural University, Wuhan 430070, PR China;2. Freshwater Aquaculture Collaborative Innovation Centre of Hubei Province, Wuhan 430070, PR China;3. Key Laboratory of Freshwater Biodiversity Conservation, Ministry of Agriculture, Yangtze River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Wuhan 430223, PR China |
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Abstract: | Seven minor alkaloids have been isolated from Tylophora hirsuta. The known alkaloids 14-hydroxyisotylocrebrine, (+)-isotylocrebrine, (−)-tylophorine and 4-desmethylisotylocrebrine have also been isolated in addition to three new alkaloids, namely 14-desoxy-13a-methyltylohirsutinidine, 5-hydroxy-O-methyltylophorinidine and tylohirsuticine. Structural studies indicate that the first six alkaloids possess the dibenzo-f,h]pyrrolo1,2b]isoquinoline skeleton but differ in the number, nature and distribution of the oxygen-bearing substituents, in the presence or absence of a benzylic type hydroxyl and an angular methyl function. Tylohirsuticine possesses a related septicine-type skeleton containing four oxygen-bearing substituents on the cleaved phenanthrene nucleus and an angular methyl function. |
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