Association between MCT1 T1470A polymorphism and climbing status in Polish and Japanese climbers |
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Authors: | Mika Saito Micha Ginszt Myosotis Massidda Pawe Ciszczyk Takanobu Okamoto Piotr Majcher Koichi Nakazato Naoki Kikuchi |
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Institution: | 1.Graduate School of Health and Sport Science, Nippon Sport Science University, Tokyo, Japan;2.Department of Rehabilitation and Physiotherapy, Medical University of Lublin, Poland;3.Department of Life and Environmental Sciences, University of Cagliari, Italy;4.Faculty of Physical Education, Gdańsk University of Physical Education and Sport, Gdańsk, Poland |
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Abstract: | Sport climbing will become an official event at the 2020 Tokyo Olympics; it is a popular wilderness sport among athletes and amateurs. Our previous study suggested that the T1470A polymorphism (rs1049434) of the monocarboxylate transporter 1 (MCT1) gene is associated with athletic performance and physiological phenotypes. The purpose of this study was to investigate the frequency of MCT1 T1470A polymorphism in Polish and Japanese climbers using a case-control study. Our sample consisted of 226 climbers (Japanese: n = 100, 64 male and 36 female; Polish: n = 126, 97 male and 29 female) and 1028 non-athletic controls (Japanese, n = 407; Polish = 621) who were genotyped for the MCT1 T1470A polymorphism (rs1049434) using the TaqMan SNP genotyping assay or restriction enzyme. The frequency of the TT genotype and T allele was significantly higher in climbers than in controls among the Polish subjects (genotype: p = 0.030, allele: p = 0.010); however, there were no significant differences in the genotype and allelic frequencies between the Japanese climbers and controls (genotype: p = 0.968; allele: p = 0.803). Our results suggested that the frequency of the T allele (TT+TA genotype) in the MCT1 T1470A polymorphism is over-represented in Polish climbers but not in Japanese climbers. In addition, the frequency of the T allele and TT genotype in Polish lead climbers is higher than that in controls. |
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Keywords: | Sports climbing Climbers Genotype MCT1 T1470A polymorphism |
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