Clonal growth in vitro by mouse Kupffer cells. |
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| Authors: | D M Chen H S Lin P Stahl E R Stanley |
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| Institution: | 1. Section of Cancer Biology, Divison of Radiation Oncology, Mallinckrodt Institute of Radiology and Department of Microbiology and Immunology USA;2. Department of Physiology and Biophysics, Washington University School of Medicine, St Louis, MO 63110, USA;3. Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA |
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| Abstract: | Mouse liver Kupffer cells were induced to proliferate and form discrete colonies of mononuclear phagocytes in vitro. These colony-forming cells from the liver are similar to other mononuclear phagocyte colony-forming cells in that they require a colony-stimulating factor present in medium conditioned by L cells for proliferation in vitro. Cells in the colonies were phagocytic and had IgG receptors on the membrane. For this class of colony-forming cells, the D0 value to gamma irradiation in vitro was 108 rads. |
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