Inhibition of Helicobacter pylori haemogglutination activity by human salivary mucins |
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| Authors: | A Mentis L Tzouvelekis C Spiliadis CC Blackwell DM Weir |
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| Institution: | Department of Bacteriology, Hellenic Pasteur Institute, Athens, Greece;Department of Bacteriology, University of Medical School, Edinburgh, U.K. |
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| Abstract: | Abstract Thirty isolates of Helicobacter pylori from gastric biopsies agglutinated human erthyrocyte suspensions. Crude mucin preparation derived from saliva of 20 different donors were examined for their ability to inhibit haemagglutination. All mucin preparations exhibited strong inhibitory activity. Removal of sialic residues from mucin preparations by treatment with neuraminidase resulted in a substantial reduction of their inhibitory activity. The mucin prepations had no bactericidal or aggregation activity for H. pylori . These results are discussed in the context of the role of mucins in colonization of the gastric mucosa by H. pylori |
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| Keywords: | Helicobacter pylori Mucin Haemagglutination |
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