Genomic deletion marking an emerging subclone of Francisella tularensis subsp. holarctica in France and the Iberian Peninsula |
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| Authors: | Dempsey M P Dobson M Zhang C Zhang M Lion C Gutiérrez-Martín C B Iwen P C Fey P D Olson M E Niemeyer D Francesconi S Crawford R Stanley M Rhodes J Wagner D M Vogler A J Birdsell D Keim P Johansson A Hinrichs S H Benson A K |
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| Affiliation: | Division of Microbiology, Armed Forces Institute of Pathology, Washington, DC, USA. |
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| Abstract: | Francisella tularensis subsp. holarctica is widely disseminated in North America and the boreal and temperate regions of the Eurasian continent. Comparative genomic analyses identified a 1.59-kb genomic deletion specific to F. tularensis subsp. holarctica isolates from Spain and France. Phylogenetic analysis of strains carrying this deletion by multiple-locus variable-number tandem repeat analysis showed that the strains comprise a highly related set of genotypes, implying that these strains were recently introduced or recently emerged by clonal expansion in France and the Iberian Peninsula. |
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