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Pharmacokinetic investigation of sildenafil using positron emission tomography and determination of its effect on cerebrospinal fluid cGMP levels
Authors:Vanessa Gómez‐Vallejo  Ana Ugarte  Carolina García‐Barroso  Mar Cuadrado‐Tejedor  Boguslaw Szczupak  Iria G. Dopeso‐Reyes  José L. Lanciego  Ana García‐Osta  Jordi Llop  Julen Oyarzabal  Rafael Franco
Affiliation:1. Radiochemistry Platform, CIC biomaGUNE, San Sebastian, Spain;2. Small Molecule Discovery Platform, Molecular Therapeutics Program, Centre for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain;3. Neurobiology of Alzheimer's disease, Neurosciences Division, Centre for Applied Medical Research (CIMA), University of Navarra, Pamplona, Spain;4. Anatomy Department, School of Medicine, University of Navarra, Pamplona, Spain;5. Nuclear Imaging Platform, CIC biomaGUNE, San Sebastian, Spain;6. Neurosciences Division, Centre for Applied Medical Research, CIMA, University of Navarra, Pamplona, Spain;7. Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Pamplona, Spain;8. Instituto de Investigaciones Sanitarias de Navarra (IdiSNA), Pamplona, Spain;9. Radiochemistry and Nuclear Imaging Group, CIC biomaGUNE, San Sebastian, Spain
Abstract:
Keywords:Alzheimer  biodistribution  cerebrospinal fluid (CSF)     cGMP     neurodegeneration  nootropic  Positron emission tomography
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