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TrkB activation by 7, 8‐dihydroxyflavone increases synapse AMPA subunits and ameliorates spatial memory deficits in a mouse model of Alzheimer's disease
Authors:Lei Gao  Mi Tian  Hong‐Yun Zhao  Qian‐Qian Xu  Yu‐Ming Huang  Qun‐Cao Si  Qing Tian  Qing‐Ming Wu  Xia‐Min Hu  Li‐Bo Sun  Shawn M. McClintock  Yan Zeng
Affiliation:1. Brain and Cognitive Dysfunction Research Center, School of Medicine, Wuhan University of Science and Technology, Wuhan, China;2. The Fifth Ward of Neurology Rehabilitation Center, Hangzhou Armed Police Hospital, Hangzhou, China;3. Division of Brain Stimulation and Neurophysiology, Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, North Carolina, USA;4. Department of Psychiatry, UT Southwestern Medical Center, Dallas, Texas, USA
Abstract:
Keywords:7, 8‐dihydroxyflavone  AMPA receptors  cognitive impairment  synapse structure  Tg2576 mouse  TrkB signaling
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