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Targeting innate immunity for neurodegenerative disorders of the central nervous system
Authors:Katrin I. Andreasson  Adam D. Bachstetter  Marco Colonna  Florent Ginhoux  Clive Holmes  Bruce Lamb  Gary Landreth  Daniel C. Lee  Donovan Low  Marina A. Lynch  Alon Monsonego  M. Kerry O'Banion  Milos Pekny  Till Puschmann  Niva Russek‐Blum  Leslie A. Sandusky  Maj‐Linda B. Selenica  Kazuyuki Takata  Jessica Teeling  Terrence Town  Linda J. Van Eldik
Affiliation:1. Department of Neurology and Neurological Sciences, Stanford Neuroscience Institute, Stanford University School of Medicine, Stanford, CA, USA;2. Sanders‐Brown Center on Aging, Spinal Cord and Brain Injury Research Center, and Department of Anatomy and Neurobiology, University of Kentucky, Lexington, KY, USA;3. Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA;4. Singapore Immunology Network (SIgN), Agency for Science, Technology and Research (A*STAR), Singapore;5. Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK;6. Department of Neurosciences, Cleveland Clinic, Cleveland, OH, USA;7. Alzheimer Research Laboratory, Department of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, OH, USA;8. USF Health Byrd Alzheimer's Institute, Tampa, FL, USA;9. College of Pharmacy & Pharmaceutical Sciences, Tampa, FL, USA;10. Trinity College Institute of Neuroscience, Trinity College, Dublin, Ireland;11. The Shraga Segal Dept. of Microbiology, Immunology and Genetics, The Faculty of Health Sciences, The National Institute of Biotechnology in the Negev and Zlotowski Center for Neuroscience, Ben‐Gurion University, Beer‐Sheva, Israel;12. Departments of Neuroscience and Neurology, Del Monte Neuromedicine Institute, University of Rochester School of Medicine & Dentistry, Rochester, NY, USA;13. Center for Brain Repair and Rehabilitation, Department of Clinical Neuroscience and Rehabilitation, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden;14. Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia;15. Hunter Medical Research Institute, University of Newcastle, New South Wales, Australia;16. The Dead Sea and Arava Science Center, Central Arava Branch, Yair Station, Hazeva, Israel;17. Department of Clinical and Translational Physiology, Kyoto Pharmaceutical University, Kyoto, Japan;18. Centre for Biological Sciences, University of Southampton, Southampton General Hospital, Southampton, UK;19. Departments of Physiology and Biophysics, Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
Abstract:
Keywords:Alzheimer disease  blood–  brain barrier  innate immunity  macrophage  non‐steroidal anti‐inflammatory drugs (NSAIDs)  Venusberg Neuroinflammation Meeting Bonn 2015
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