Interaction of group A streptococci with human plasmin(ogen) under physiological conditions |
| |
Authors: | D'Costa S S Boyle M D |
| |
Institution: | Department of Microbiology and Immunology, Medical College of Ohio, 3055 Arlington Avenue, Toledo, Ohio 43614-5806, USA. |
| |
Abstract: | A series of methods for analyzing the interaction of group A streptococci with the human plasminogen system are described. Examples of group A streptococcal isolates capable of assembling surface plasminogen activator activity when grown in human plasma are presented and the key requirements for this process are evaluated. The stabilities of cell-associated plasmin and plasminogen activator complexes are compared and a model for the interaction of group A streptococci with the plasminogen system in an infected host is presented. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|