Localization of HLA on the short arm of chromosome 6 |
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| Authors: | Martijn H Breuning Ella M van den Berg-Loonen Luigi F Bernini Jan B Bijlsma Erna van Loghem P Meera Khan Lourens E Nijenhuis |
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| Institution: | (1) Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Amsterdam, The Netherlands;(2) Department of Human Genetics, State University of Leyden, Leyden, The Netherlands;(3) Department of Human Genetics, University of Amsterdam, Sarphatistraat 217, Amsterdam, The Netherlands |
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| Abstract: | Summary A detailed marker gene study in a large Dutch kindred segregating for a reciprocal translocation between the chromosomes 6 and 20, t(6;20) (p21;p13), revealed a close linkage between the HLA genes and the breakpoint on the short arm of 6. During this study an apparent peak lod score of 2.9 was obtained at a recombination value of 0.05 for a linkage between HLA and the breakpoint, indicating that the chromosomal region, carrying the HLA genes, is situated near the breakpoint in band 6p21 close to the transition to 6p22. |
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