Isolation and Structure Elucidation of Epipolasterol and 22,23-Dihydroepipolasterol from the Marine Sponge Epipolasis sp. |
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| Authors: | Russell G Kerr Cathy Foss Shigeki Matsunaga Nobuhiro Fusetani |
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| Institution: | aDepartment of Chemistry and Biochemistry, Florida Atlantic University, Boca Raton, FL 33431, U.S.A.;bLaboratory of Aquatic Natural Products Chemistry, Faculty of Agriculture, The University of Tokyo, Tokyo 113, Japan |
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| Abstract: | Two new sterols, epipolasterol and 22(23)-dihydroepipolasterol, have been isolated from the marine sponge Epipolasis sp. These are unusual metabolites as they both contain a t-butyl group in the sterol side chain. In addition, the presence of two degrees of unsaturation in the side chain of epipolasterol is rare. The known sterol, 22-dehydro-24-isopropylcholesterol was also found in this sponge. |
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| Keywords: | Sterol epipolasterol marine sponge Epipolasis biosynthesis |
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