Histone H3.3 G34 Mutations Alter Histone H3K36 and H3K27 Methylation In Cis |
| |
| Authors: | Leilei Shi Jiejun Shi Xiaobing Shi Wei Li Hong Wen |
| |
| Institution: | 1. Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA;2. Dan L. Duncan Cancer Center, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA;3. Van Andel Research Institute, 333 Bostwick Ave NE, Grand Rapids, Michigan 49503, USA |
| |
| Abstract: | Histone H3 encoding genes, particularly H3F3A and H3F3B, the genes encoding the variant histone H3.3, are mutated at high frequency in pediatric brain and bone malignancies. Compared to the extensive studies on K27M and K36M mutations, little is known about the mechanism of G34 mutations found in pediatric glioblastoma or giant cell tumors of the bone. Here we report that unlike the K27M or K36M that affect global histone methylation, the giant cell tumors of the bone G34 mutations (G34L/W) only affect histone H3K36 and H3K27 methylation on the same mutated histone tails (in cis), a mechanism distinct from known histone mutations. |
| |
| Keywords: | histone variant H3 3 G34 mutations SETD2 giant cell tumor of the bone GBM glioblastoma WT wild-type |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
