Binding of tryptamine analogs at h5-HT1E receptors: a structure-affinity investigation |
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| Authors: | Dukat Małgorzata Smith Carol Herrick-Davis Katharine Teitler Milt Glennon Richard A |
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| Institution: | Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298, USA. |
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| Abstract: | Structure-affinity requirements for the binding of serotonin (5-HT) analogs at human 5-HT1E receptors were investigated by examining the affinities of >40 tryptamine-related compounds. No tryptamine analog was found to bind with substantially higher affinity than 5-HT. The results indicate that hydrogen bonding plays a key role in the 5-HT1E/receptor interaction. This finding was supported using quantitative structure-activity analysis (QSAR) techniques such as comparative molecular field analysis (CoMFA) and the program QsarIS. |
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