| 内皮素对大鼠肠系膜微血管的作用 |
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| 引用本文： | 张静,汤健.内皮素对大鼠肠系膜微血管的作用[J].生理学报,1991,43(1):98-101. |
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| 作者姓名： | 张静 汤健 |
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| 作者单位： | 张家口医学院病理生理教研室 张家口075029
(张静，姜华，樊贵)，北京医科大学心肺内分泌研究室 北京100083
(汤健)，北京医科大学心肺内分泌研究室 北京100083(唐朝枢) |
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| 摘 要： | 应用显微电视录象技术可观察到内皮素(ET)对戊巴比妥钠麻醉的 Wistar 大鼠的肠系膜微血管有收缩作用,血液流速减慢,甚至产生微循环障碍,这个作用相当持久,并呈剂量依赖关系。ET 的这个作用远高于去甲肾上腺素。这些结果提示,ET 作为强烈的微血管收缩剂,在微循环紊乱疾病的发病学中可能具有重要意义。
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| 关 键 词： | 微血管 内皮素 血管收缩剂 |
EFFECT OF ENDOTHELIN ON RAT MESENTERIC MICROVESSELS |
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| ZHANG JING,JIANG HUA,FAN GUI.EFFECT OF ENDOTHELIN ON RAT MESENTERIC MICROVESSELS[J].Acta Physiologica Sinica,1991,43(1):98-101. |
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| Authors: | ZHANG JING JIANG HUA FAN GUI |
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| Institution: | Department of Pathophysiology, Zhangjiakou Medical College. |
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| Abstract: | By video microscope,it was observed that endothelin(ET)caused constrictionof the mesenteric microvessels of pentobarbital-anesthetized Wistar rats in a dose-dependent manner.With the consequence of causing a decrease of rate of bloodflow and even some microcirculation disorder,the action was long lasting.Theconstrictive effect of ET on microvessel was much stronger than norepinephrine.The results suggest that ET is a potent vasoconstrictor for microvessel and mayplay an important role in causing microcirculatory disorder. |
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| Keywords: | endothelin microvessel vasoconstrictor norepinephrine |
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