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精准医学基础研究与临床实践的回顾与展望
引用本文:高建林,魏美芳,周晓燕,柯开富,桑爱民,管又飞,程纯,沈树泉.精准医学基础研究与临床实践的回顾与展望[J].生理科学进展,2017(4):241-248.
作者姓名:高建林  魏美芳  周晓燕  柯开富  桑爱民  管又飞  程纯  沈树泉
作者单位:1. 南通大学附属医院;2. 复旦大学附属肿瘤医院;3. 南通大学附属医院;南通大学;4. 大连医科大学;5. 南通大学;6. Institute for Health Informatics, Clinical Translational Science Institute, Academic Health Center, University of Minnesota
摘    要:精准医学是健康卫生和医学科学的发展方向,是发展了一个多世纪的现代医学实践的升级版。本文研究了医学科研和医疗实践的发展趋势,从分子遗传、环境变迁及医疗信息管理等领域,分析和总结了影响精准医学发展的一些因素,提出了精准医学基础研究和临床实践的一些新思路,希望对精准医学的发展、医学科研实践及医疗卫生政策的制定产生积极的影响。

关 键 词:精准医学  分子遗传  表观遗传学  生物与医学信息

Perspectives on Personalized Precision Medicine: Problems and Challenges in Research and Clinical Practice
GAO Jian-Lin,WEI Mei-Fang,ZHOU Xiao-Yan,KE Kai-Fu,SANG Ai-Ming,GUAN You-Fei,CHENG Chun,Steven S.Shen.Perspectives on Personalized Precision Medicine: Problems and Challenges in Research and Clinical Practice[J].Progress in Physiological Sciences,2017(4):241-248.
Authors:GAO Jian-Lin  WEI Mei-Fang  ZHOU Xiao-Yan  KE Kai-Fu  SANG Ai-Ming  GUAN You-Fei  CHENG Chun  Steven SShen
Abstract:Personalized precision medicine is a strategic direction of development of modern medical science andan extreme goal of the clinicalpractice.For research, education, medical practice and governing purpose, we discussed and analyzed several aspects of the new developments in the fieldof precision medicine.We also summarized some of the key factors that may affect basic research and clinical practice in the field.We pointed out that some of the areas are rapid expanding in recent years that will impact medical science in long term.We hope that this article will be able to provide some thinking points for our Chinese medical community.
Keywords:precision medicine  molecular genetics  epigenetics  medical informatics  bioinformatics
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