介导硫化氢生理/病理学效应的靶分子及其分子开关调节的原子生物学机制

硫化氢(H_2S)作为继一氧化氮和一氧化碳后的第三种气体信号分子,日渐受到人们的关注,检测技术的发展为研究提供了帮助。H_2S在人体各系统中发挥着重要的作用,如心血管系统、神经系统、呼吸系统等,其与高血压、动脉粥样硬化、神经退行性疾病、哮喘等疾病的发生发展有着密切的联系,具有作为疾病治疗药物的潜能。对于H_2S作用于靶分子机制的阐述深化了小分子物质调控大分子功能的研究,提供了对多种疾病进行干预的新手段。

The Molecular Switches and Atomic Biological Mechanisms Underlying the Physiological and Pathophysio-logical Effects of Hydrogen Sulfide to Regulate Its "Receptors"

Hydrogen sulfide (H2S)has emerged as pivotal signaling molecules since it is recognized as the third gasotrans-mitter together with nitric oxide and carbon monoxide.The development of detecting technologies contributed to the research in H2S biology.H2S plays significant roles in human body systems,such as the cardiovascular system,nervous system,re-spiratory system etc..Alterations of H2S concentrations have been connected with many diseases.Hypertension,athero-sclerosis,neurodegenerative disorder,asthma and many other diseases are found to be related with abnormal H2S metabo-lism.It has become a potential drug for therapeutic purposes.Understanding the mechanism of H2S biology,including a molecular switch contained in its "receptor",has deepened the research on how small molecules regulate big molecules,as well as providing new strategy for the therapeutic approaches for varies of diseases.