A high-throughput chemically induced inflammation assay in zebrafish |
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| Authors: | Claudia A d'Alençon Oscar A Peña Christine Wittmann Viviana E Gallardo Rebecca A Jones Felix Loosli Urban Liebel Clemens Grabher Miguel L Allende |
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| Institution: | (1) Center for Genome Regulation, Facultad de Ciencias, Universidad de Chile, Santiago, Chile;(2) Departamento de Ciencias Biologicas, Facultad de Ciencias Biologicas, Universidad Andres Bello, Santiago, Chile;(3) Institute of Toxicology and Genetics, Karlsruhe Institute of Technology, Hermann von Helmholtz Platz 1, D-76344 Eggenstein-Leopoldshafen, Germany;(4) Department of Biochemistry, School of Medical Sciences, University of Bristol, BS2 8HD Bristol, UK |
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| Abstract: | Background Studies on innate immunity have benefited from the introduction of zebrafish as a model system. Transgenic fish expressing
fluorescent proteins in leukocyte populations allow direct, quantitative visualization of an inflammatory response in vivo. It has been proposed that this animal model can be used for high-throughput screens aimed at the identification of novel
immunomodulatory lead compounds. However, current assays require invasive manipulation of fish individually, thus preventing
high-content screening. |
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