Azithromycin effectiveness against intracellular infections of Francisella |
| |
| Authors: | Saira Ahmad Lyman Hunter Aiping Qin Barbara J Mann Monique L van Hoek |
| |
| Affiliation: | (1) Department of Molecular and Microbiology, National Center for Biodefense and Infectious Diseases, George Mason University, 20120 Manassas, VA, USA;(2) Inova Fairfax Hospital, 22042 Falls Church, VA, USA;(3) Departments of Medicine & Microbiology, University of Virginia Health Systems, 22908 Charlottesville, VA, USA |
| |
| Abstract: | Background Macrolide antibiotics are commonly administered for bacterial respiratory illnesses. Azithromycin (Az) is especially noted for extremely high intracellular concentrations achieved within macrophages which is far greater than the serum concentration. Clinical strains of Type B Francisella (F.) tularensis have been reported to be resistant to Az, however our laboratory Francisella strains were found to be sensitive. We hypothesized that different strains/species of Francisella (including Type A) may have different susceptibilities to Az, a widely used and well-tolerated antibiotic. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
