Heterologous mevalonate production in Streptomyces lividans TK23 |
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| Authors: | Kuzuyama Tomohisa Dairi Tohru Yamashita Haruyuki Shoji Yoshikazu Seto Haruo |
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| Affiliation: | Institute of Molecular and Cellular Biosciences, The University of Tokyo, Japan. utkuz@mail.ecc.u-tokyo.ac.jp |
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| Abstract: | Mevalonate is a ubiquitous biosynthetic intermediate of terpenoids and is used as a moisturizer in cosmetics and a chemical for biochemical research. In this study, we have achieved a heterologous production of this useful compound by expression in Streptomyces lividans TK23 of 3-hydroxy-3-methylglutaryl-CoA synthase and 3-hydroxy-3-methylglutaryl-CoA reductase genes, which were cloned from Streptomyces sp. strain CL190. |
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