Alteration in the Postnatal Ontogeny of Cerebellar Norepinephrine Content Following Chronic Prenatal Carbon Monoxide |
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Authors: | Jan E Storm Laurence D Fechter |
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Institution: | Department of Environmental Health Services, Johns Hopkins University, Baltimore, Maryland, U.S.A. |
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Abstract: | The postnatal ontogeny of norepinephrine content in the cortex and cerebellum was determined in rats exposed prenatally to a chronic low level of carbon monoxide (150 parts per million). In the cerebellum, norepinephrine concentration and total norepinephrine content among carbon monoxide-exposed rats were consistently elevated over that of control rats from the second through the sixth postnatal weeks. In the cortex, norepinephrine concentration and total norepinephrine content among carbon monoxide-exposed rats did not differ from that of control rats over the same period. These results identify the cerebellum as a region whose postnatal development is altered by prenatal exposure to low levels of carbon monoxide-induced hypoxia. |
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Keywords: | Carbon monoxide Hypoxia Cerebellum Ontogeny Norepinephrine |
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