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Cryptococcus neoformans varieties as agents of cryptococcosis in Brazil |
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| Authors: | Ronaldo Rozenbaum Adrelirio José Rios Gonçalves Bodo Wanke Maria Julieta Caiuby Hamilton Clemente Marcia dos Santos Lazera Paulo Cesar Fialho Monteiro Alberto Thomaz Londero |
| Institution: | (1) Serviço de Doenças Infecciosas e Parasitarárias, Hospital dos Servidores do Estado, Rio de Janeiro, RJ, Brasil;(2) Serviço de Micologia, Hospital Evandro Chagas, Institute Oswaldo Cruz, Rio de Janeiro, RJ, Brasil;(3) Serviço de Micologia, Hospital Universitário da Universidade Federal, Rio de Janeiro, RJ, Brasil;(4) Pesquisador 1-A do Conselho Nacional de Desenvolvimento Cientifico e Tecnológico/CNPq, Brasil |
| Abstract: | The study of the clinical isolates of Cryptococcus neoformans from 83 Brazilian patients with disseminated cryptococcosis showed that 75 were C. neoformans var. neoformans and 8 were var. gattii. Twenty-seven isolates were serotyped; all 19 var. neoformans were serotype A and all 8 var. gattii were serotype B. The correlation of the varieties of C. neoformans with the presence or not of hosts predisposing conditions to the mycosis showed that: (1) cryptococcosis caused by gattii variety occurred in 7 (58.3%) of the 12 nonimmunosuppressed patients, and (2) cryptococcosis caused by neoformans variety occurred in 65 (98.5%) of the 66 AIDS patients and in all 5 patients with other immunosuppressive conditions. The comparison of the distribution of the gattii and neoformans varieties between the nonimmunosup-pressed and immunosuppressed patients showed a significant statistical difference (p < 0.01). |
| Keywords: | Cryptococcus neoformans cryptococcosis varieties |
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