Collagen-bound LDL modifies endothelial cell adhesion to type V collagen: Implications for atherosclerosis |
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Authors: | Stefan Lorkowski Jürgen Rauterberg Bärbel Harrach-Ruprecht David Troyer |
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Institution: | (1) Institute of Biophysics and Nanosystems Research, Austrian Academy of Sciences, Schmiedlstr. 6, 8042 Graz, Austria |
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Abstract: | Low density lipoprotein (LDL) is retained in the extracellular matrix of the arterial wall where it is considered to be atherogenic,
but little is known about how cell adhesion to the matrix is affected by collagen-bound LDL. We tested the effect of native,
oxidized and acetylated LDL reacted with adsorbed monomeric type I, III and V collagen on endothelial cell adhesion to collagen
using a colorimetric adhesion assay. We found that none of the LDL species affected adhesion to type I and III collagen, but
that collagen-bound native and acetylated LDL enhanced attachment to type V collagen, whereas bound oxidized LDL inhibited
adhesion to this collagen. We therefore suggest that oxidized LDL associated with type V collagen in the arterial wall would
favor de-endothelialization and contribute to atherogenesis and thrombosis. |
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