On the antibiotic activity of oxazolomycin |
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Authors: | Bagwell Claire L Moloney Mark G Thompson Amber L |
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Affiliation: | aDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK |
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Abstract: | Structural analysis of oxazolomycin and simpler fragments containing a common 3-hydroxy-2,2-dimethylpropanamide moiety has indicated that a U-shaped conformation is preferred, in some cases stabilised by hydrogen bonding between the N–H and O–H residues, as shown by a combination of molecular modelling, NMR spectroscopic and single crystal X-ray analysis. A direct synthesis of this unit has been established via the opening of β-lactones by a range of amines, and their antibacterial activity been shown to vary with the hydrophobic character of the substituents. |
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Keywords: | Oxazolomycin Antibiotic Bioactivity Conformation |
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