| 臂旁核和延髓头端腹外侧区在黑质升压效应中的作用 |
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| 引用本文： | 张黎明,顾蕴辉.臂旁核和延髓头端腹外侧区在黑质升压效应中的作用[J].动物学报,1989(3). |
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| 作者姓名： | 张黎明 顾蕴辉 |
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| 作者单位： | 北京医科大学生理学教研室
(张黎明)，北京医科大学生理学教研室(顾蕴辉) |
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| 摘 要： | 本实验室观察到黑质具有升压效应。用L-谷氨酸钠微量注入黑质可使血压升高,此效应可被DA受体阻断剂氟哌啶醇(Halo)微量注入臂旁核加压区基本阻断。我们过去的工作证明延髓头端腹外侧区(RVL)及其内的α-受体中介臂旁核的加压效应,本实验将酚妥拉明注入RVL能明显衰减黑质的加压效应,而将Halo注入RVL加压区对黑质加压效应无明显影响。以上结果提示臂旁核-RVL(α-受体)加压系统参与黑质加压效应。
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ROLE OF PARABRACHIAL NUCLEUS IN PRESSOR EFFECT OF SUBSTANTIA NIGRA IN THE RAT |
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| ZHANG LIMING AND KU.ROLE OF PARABRACHIAL NUCLEUS IN PRESSOR EFFECT OF SUBSTANTIA NIGRA IN THE RAT[J].Acta Zoologica Sinica,1989(3). |
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| Authors: | ZHANG LIMING AND KU |
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| Abstract: | Besides its somatic motor and pain-regulation functions, we observed that substantia nig-ra (SN) had a pressor effect. Sodium glutamate-microinjection into SN produced a rise in blood pressure which could be blocked by haloperidol injection into bilateral parabrachial nucleus (NPB) but not by haloperidol injection into rostral ventrolateral medulla (RVL). Our previous study demonstrated that RVL and aaaaaaaaaaaaaaaa-adrenoceptors within it mediated the NPB-pre-ssor effect. The present study showed that bilateral injection of phentolamine into RVL attenuated the pressor effect of SN, but no effect on the pressor effect of SN by haloperidol ingec-tion NPB. These result suggest that the NPB-RVL (a-receptor) pressor system is involved in the pressor effect 6f SN. |
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| Keywords: | Substantia nigra Parabrachial nucleus Rostral ventrolateral medulla Pressor effect Haloperidol |
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