Spantide III,a superior tachykinin antagonist with high potency and negligible neurotoxicity |
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| Authors: | K. Folkers R. Hakanson D. M. Feng J. C. Xu A. Janecka Z. -Y. Wang |
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| Affiliation: | (1) Institute for Biomedical Research, University of Texas at Austin, 78712 Austin, TX, USA;(2) Department of Pharmacology, Lund University, Lund, Sweden |
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| Abstract: | Summary Five new antagonists of Substance P were designed and synthesized toward increasing potency and safety. One of them was more effective than Spantide II, which was the basis for the design. It was named Spantide III and has the structure: D-NicLys,Pro,Pal,Pro,D-Cl2Phe,Asn,D-Trp,Phe,D-Pal,Leu, NleNH2. |
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| Keywords: | Amino acids Substance P antagonists Spantide III Solid phase peptide synthesis |
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