Structural and immunogenomic insights into B-cell receptor activation |
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Affiliation: | 1. Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, The Ministry of Education Key Laboratory, National Clinical Research Center for Dermatologic and Immunologic Diseases, Shuafuyuan, Dongcheng District, Beijing 100730, China;2. Department of Rheumatology and Clinical Immunology, The First People''s Hospital of Yueyang, Yueyang, Hunan 414000, China;3. Department of Rheumatology and Clinical Immunology, The First People''s Hospital of ChenZhou, ChenZhou, Hunan 423000, China;4. MOE Key Laboratory of Protein Sciences, Center for Life Sciences, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, School of Life Sciences, Beijing Key Lab for Immunological Research on Chronic Diseases, Institute for Immunology, Tsinghua University, Beijing 100084, China;1. Grupo de Inmunología Celular e Inmunogenética (GICIG), Sede de investigación Universitaria (SIU), Facultad de Medicina, Universidad de Antioquia, Carrera 53, # 61-30, Medellín, Colombia;2. Grupo de Reumatología, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia;3. Sección Reumatología, Hospital Universitario San Vicente Fundación, Medellín, Colombia;4. Centro Nacional de Enfermedades Reumáticas, Hospital Universitario de Caracas, Carcas, Venezuela;5. Unidad de Citometria, Universidad de Antioquia, Colombia |
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Abstract: | B cells express B-cell receptors(BCRs) which recognize antigen to trigger signaling cascades for B-cell activation and subsequent antibody production. BCR activation has a crucial influence on B-cell fate. How BCR is activated upon encountering antigen remains to be solved, although tremendous progresses have been achieved in the past few years. Here, we summarize the models that have been proposed to explain BCR activation, including the cross-linking model, the conformation-induced oligomerization model, the dissociation activation model, and the conformational change model. Especially, we elucidate the partially resolved structures of antibodies and/or BCRs by far and discusse how these current structural and further immunogenomic messages and more importantly the future studies may shed light on the explanation of BCR activation and the relevant diseases in the case of dysregulation. |
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Keywords: | B-cell receptor B-cell activation BCR structure Immunogenomics |
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