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Application of Covariance Analysis to Ophtalmologic Research
Authors:K-D Wernecke  W D Ulrich
Abstract:Using covariance analysis as an adjusted regression analysis it is possible, with the assumption of homogeneity and normality of variance, to test several regression functions for homogeneity, if the given groups of data material are independent. This well-known analysis is applied to a number of examination methods of ophthalmology. In the cases of ophthalmo-dynamography (ODG) and ophthalmo-dynamometry (ODM), the paper answers the question to what extent the result of ophthalmologic measurement is influenced by posture (sitting — lying — standing). Contrary to several authors' practice of combining the regression lines for the systolic and diastolic blood-pressure because of the improvement of the correlation coefficient to be achieved in this way, it was possible to show that generally such an approach is not recommendable. Patients suffering from a certain type of arteriosclerosis distinguish themselves by deviations of their ODG data from the normal blood-pressure relation of the arteria carotis interna and the arteria brachialis. These differences can be tested for statistical significance by means of covariance analysis.
Keywords:Covariance analysis  adjusted regression analysis  influence of ophtalmologic measurements by posture
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