A new UV-B absorbing mycosporine with photo protective activity from the lichenized ascomycete Collema cristatum. |
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| Authors: | Avital Torres Malka Hochberg Inna Pergament Reem Smoum Valerie Niddam Valery M Dembitsky Marina Temina Inka Dor Ovadia Lev Morris Srebnik Claes D Enk |
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| Affiliation: | Department of Medicinal Chemistry and Natural Products, School of Pharmacy, Hebrew University of Jerusalem, Israel. |
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| Abstract: | A novel photo protective mycosporine was isolated from the lichenized ascomycete Collema cristatum. Biological activity was measured in terms of protection against UV-B induced membrane destruction and pyrimidine dimer formation in cultured human keratinocytes, and prevention of UV-B induced erythema. It was found that the pure isolated compound prevented UV-B induced cell destruction in a dose-dependent manner, that the compound partially prevented pyrimidine dimer formation and completely prevented UV-B induced erythema when applied to the skin prior to irradiation. |
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