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Phenylpiperazine derivatives with strong affinity for 5HT1A, D2A and D3 receptors |
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| Authors: | Carmen Terá n,Lourdes Santana,Eugenio Uriarte,Yagamare Fall,Lena Unelius,Bo-Ragnar Tolf |
| Affiliation: | a Department of Physical Chemistry and Organic Chemistry, University of Vigo, 36200, Vigo, Spain b Department of Organic Chemistry, Faculty of Pharmacy, University of Santiago, 15706, Santiago, Spain c Astra Arcus AB, Preclinical Research & Development, S-151 85, Södertälje, Sweden |
| Abstract: | Four 7-[3-(4-phenyl-1-piperazinyl)propoxy]coumarins were synthesized. The affinities of these compounds for DA (D2A, D3) and 5HT1A receptors were evaluated for their ability to displace [3H]-raclopride and [3H]-8-OH-DPAT respectively from their specific binding sites. The affinities of the target compounds were all in the nanomolar range and followed the order 5-HT1A > D2 > D3. |
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