Reevaluation of circulating prostacyclin and thromboxane in diabetes |
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| Institution: | 1. Al-Balqa'' Applied University, Al-Salt, Jordan;2. Sunnybrook Health Sciences Centre, Toronto, ON, Canada;3. Department of Medical Imaging, University of Toronto, Toronto, ON, Canada;4. Yarmouk University Faculty of Medicine, Irbid, Jordan;5. University of Western Ontario, 1151 Richmond St, London, ON N6A 5B9, Canada |
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| Abstract: | Although several investigators have attempted to measure the plasma levels of prostacyclin (PGI2) and thromboxane A2 (TXA2) in diabetes and normal subjects, their results have been controversial. In this study, we measured plasma PGI2 and TXA2 levels in diabetic patients and normal subjects. The plasma PGI2 and TXA2 were determined by RIA as 6-keto-PGF1a and TXB2, respectively. The plasma levels of 6-keto-PGF1a were significantly reduced in diabetics with microangiopathy (52.5 ± 18.9 pg/ml, mean ± SE, p<0.05) compared with those of normal subjects. Diabetics as a whole also showed lower levels of 6-keto-PGF1a than normal subjects (57.8 ± 26.1 vs. 70.2 ± 20.7 pg/ml), though this was not significant statistically. The plasma 6-keto-PGF1a levels did not significantly correlate with either age of the patients or duration of diabetes in diabetics. Interestingly, however, hemoglobin Alc significantly correlated inversely with 6-keto-PGF1a levels in diabetics without microangiopathy (r=?0.60, p<0.05). The plasma levels of TXB2 in diabetics were significantly higher than those of normal subjects (155.2 ± 69.5 vs. 108.0 ± 30.0 pg/ml, p<0.05). These data suggest that an imbalance of circulating PGI2 and TXA2 may contribute to the development of diabetic microangiopathy. |
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