Monoamine oxidase inhibitors from Gentiana lutea |
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| Authors: | Haraguchi Hiroyuki Tanaka Yasumasa Kabbash Amal Fujioka Toshihiro Ishizu Takashi Yagi Akira |
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| Affiliation: | Faculty of Life Science and Biotechnology, Fukuyama University, Gakuen-cho, Fukuyama 729-0292, Japan. haragu@bt.fubt.fukuyama-u.ac.jp |
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| Abstract: | Three monoamine oxidase (MAO) inhibitors were isolated from Gentiana lutea. Their structures were elucidated to be 3-3'linked-(2'-hydroxy-4-O-isoprenylchalcone)-(2'-hydroxy-4'-O-isoprenyldihydrochalcone) (1), 2-methoxy-3-(1,1'-dimethylallyl)-6a,10a-dihydrobenzo(1,2-c)chroman-6-one and 5-hydroxyflavanone. These compounds, and the hydrolysis product of 1, displayed competitive inhibitory properties against MAO-B which was more effective than MAO-A. |
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| Keywords: | Gentiana lutea Gentianaceae Monoamine oxidase 3-3″Linked-(2′-hydroxy-4-O-isoprenylchalcone)-(2?-hydroxy-4″-O-isoprenyldihydrochalcone) 2-Methoxy-3-(1,1′-dimethylallyl)-6a,10a-dihydrobenzo(1,2-c)chroman-6-one 5-Hydroxyflavanone |
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