L-thyroxine and L-triiodothyronine in the cerebral tissues of the adult rat. Effect of hypothyroidism] |
| |
Authors: | A Serrano-Lozano P Morata M Montiel J P Pérez-Aguilar M Morell |
| |
Affiliation: | Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Universidad de Málaga, Espa?a. |
| |
Abstract: | The L-thyroxine and L-triiodothyronine concentrations in several brain areas (cerebral cortex, brain stem, hypothalamus, total brain and hypophysis) in normal and hypothyroid rats have been studied. Results show that L-thyroxine values at tissue level are inferior in the hypothyroid group, although non-significant with respect to the control group, whereas L-triiodothyronine presents values similar to the hypothyroid group and its control in all the brain regions studied with the exception of hypophysis. These results show that in hypothyroid situations exist a compensatory mechanism for maintaining the adequate L-triiodothyronine levels in several brain areas, although the serum levels are strongly decreased in hypothyroid animals. |
| |
Keywords: | |
|
|