Synthesis of a key Mycobacterium tuberculosis biosynthetic phosphoinositide intermediate |
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| Authors: | Jayaprakash K N Lu Jun Fraser-Reid Bert |
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| Affiliation: | Natural Products and Glycotechnology Research Institute, Inc., (NPG), 4118 Swarthmore Road, Durham, NC 27706, USA. |
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| Abstract: | Regioselective mannosylations of a myoinositol acceptor diol are readily achieved by Lewis acid mediated iodinolysis of n-pentenyl ortho-esters. The procedure affords a psuedotrisaccharide to which the phosphoglyceryl and other lipid residues are added leading to the key biosynthetic intermediate of Mycobacterium species. |
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