Similarity of Recombinant Human Perlecan Domain 1 by Alternative Expression Systems Bioactive Heterogenous Recombinant Human Perlecan D1期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Similarity of Recombinant Human Perlecan Domain 1 by Alternative Expression Systems Bioactive Heterogenous Recombinant Human Perlecan D1

Authors:	April L Ellis Wensheng Pan Guang Yang Kim Jones Christine Chuang John M Whitelock Arthur A DeCarlo

Institution:	(1) Agenta Biotechnologies, Inc., Innovation Depot, 1500 1st Ave. N, 35203 Birmingham, AL, USA;(2) Southern Research Institute, 35205 Birmingham, AL, USA;(3) University of Alabama at Birmingham, 35294 Birmingham, AL, USA;(4) Graduate School of Biomedical Engineering, University of New South Wales, Sydney, Australia

Abstract:	Background Heparan sulfate glycosaminoglycans are diverse components of certain proteoglycans and are known to interact with growth factors as a co-receptor necessary to induce signalling and growth factor activity. In this report we characterize heterogeneously glycosylated recombinant human perlecan domain 1 (HSPG2 abbreviated as rhPln.D1) synthesized in either HEK 293 cells or HUVECs by transient gene delivery using either adenoviral or expression plasmid technology.

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