A new type of cysteine proteinase inhibitor--the salarin gene from Atlantic salmon (Salmo salar L.) and Arctic charr (Salvelinus alpinus) |
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Authors: | Olonen Anne Kalkkinen Nisse Paulin Lars |
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Institution: | Protein Chemistry Laboratory, Institute of Biotechnology, University of Helsinki, P.O. Box 65, 00014, Helsinki, Finland. anne.olonen@helsinki.fi |
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Abstract: | Salarin is a 43 kDa glycoprotein which is found so far only in salmonid fish species. It is a strong inhibitor of cysteine proteinases. Here we characterised the salarin gene from Atlantic salmon and cDNA from Arctic charr. The salarin gene has 13 exons and 1026 bp long coding sequence. The translated amino acid sequence has four similar domains. The sequence resembles the proregion of cathepsins, known to inhibit cysteine proteinases. Salarin can be a new type of cysteine proteinase inhibitor. |
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