Evaluation of mutagenicity of the antitubercular naphthylglycine hydrazides insalmonella typhimurium |
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Authors: | B Ramamurthy S B Pai T Ramakrishnan |
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Institution: | (1) Microbiology and Cell Biology Laboratory, Indian Institute of Science, 560012 Bangalore, India |
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Abstract: | N-(2-naphthyl)glycine hydrazide and N-methyl-N-(2-naphthyl) glycine hydrazide, which inhibitMycobacterium tuberculosis H37 RV and show activity against experimental tuberculosis, were evaluated for their mutagenic potential inSalmonella typhimurium. Both the compounds at concentration ranges from 0.1 Μgplate to 1000 Μg/plate failed to induce mutations at the histidine
locus either directly or after treatment with rat liver homogenate fraction-“S-9”. N-(2-naphthyl)glycine hydrazide and its
N-methyl derivative elicited toxicity at concentrations of 500 Μg/plate and 1000 Μg/plate. However, in the presence of the
liver homogenate system, reduction in toxicity was noticed probably due to detoxification and/ or conjugation of the compounds.
Under the assay conditions employed, standard mutagens like 4-nitroquinoline-N-oxide, 9-aminoacridine and benzo(a)pyrene were positive. The non-mutagenic nature of N-(2-naphthyl)glycine hydrazide and N-methyl-N-(2-naphthyl)glycine hydrazide
should enhance their potential for inclusion in treatment protocols for management of tuberculosis |
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Keywords: | N-(2-naphthyl)glycine hydrazide N-methyl-N-(2-naphthyl) glycine hydrazide Salmonella typhimurium mutagenicity antitubercular hydrazides |
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