The <Emphasis Type="Italic">Tnfrh1</Emphasis> (<Emphasis Type="Italic">Tnfrsf23</Emphasis>) gene is weakly imprinted in several organs and expressed at the trophoblast-decidua interface期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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The <Emphasis Type="Italic">Tnfrh1</Emphasis> (<Emphasis Type="Italic">Tnfrsf23</Emphasis>) gene is weakly imprinted in several organs and expressed at the trophoblast-decidua interface

Authors:	Lorraine?Clark Michelle?Wei Giorgio?Cattoretti Cathy?Mendelsohn Email author" target="_blank">Benjamin?Tycko Email author

Institution:	1.Institute for Cancer Genetics, Columbia University College of Physicians and Surgeons,New York,USA;2.Department of Pathology,Columbia University College of Physicians and Surgeons,New York,USA;3.Department of Urology,Columbia University College of Physicians and Surgeons,New York,USA

Abstract:	Background The Tnfrh1 gene (gene symbol Tnfrsf23) is located near one end of a megabase-scale imprinted region on mouse distal chromosome 7, about 350 kb distant from the nearest known imprinting control element. Within 20 kb of Tnfrh1 is a related gene called Tnfrh2 (Tnfrsf22) These duplicated genes encode putative decoy receptors in the tumor necrosis factor (TNF) receptor family. Although other genes in this chromosomal region show conserved synteny with genes on human Chr11p15.5, there are no obvious human orthologues of Tnfrh1 or Tnfrh2.

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