Bombyx mori prothoracicostatic peptide inhibits ecdysteroidogenesis in vivo |
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Authors: | Liu Xin Tanaka Yoshiaki Song Qisheng Xu Bujin Hua Yuejin |
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Affiliation: | Institute of Nuclear-Agricultural Science, Zhejiang University, Zhejiang, China. |
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Abstract: | Bombyx prothoracicostatic peptide (Bom-PTSP) is a brain neuropeptide that has recently been reported to have in vitro inhibitory activity to prothoracicotropic hormone (PTTH)-stimulated ecdysteroid biosynthesis in the prothoracic gland of the silkworm, Bombyx mori. In the present report, Bom-PTSP has been shown to significantly decrease hemolymph ecdysteroid titer in the fifth instar larvae when Bom-PTSP was injected into the fifth instar day 8 silkworm larvae, resulting in significant delay in spinning behavior. This is the first evidence that Bom-PTSP inhibits in vivo ecdysteroidogenesis in the silkworm. |
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Keywords: | Bombyx mori prothoracicostatic peptide ecdysteroid ecdysteroidogenesis in vivo |
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