Effects of dehydroepiandrosterone sulfate on induced apoptosis of lymphocytes in healthy persons

The effect of dehydroepiandrosterone sulfate on oxidative stress- and ethanol-induced morphological changes and the level of apoptotic enzymes (Bcl-2 and caspase-3) of lymphocytes in six healthy persons were studied. It was shown that hydroperoxide induced apoptotic changes in lymphocytes. The addition of ethanol to the culture medium caused no significant changes in the parameters studied. Dehydroepiandrosterone sulfate had a marked antiapoptotic effect on the peripheral blood lymphocytes of healthy subjects, protecting them from the harmful effects of reactive oxygen species.