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The proteolytic enzymes as a highly sensitive criterion of effectiveness and safety of treatment
Authors:J R Efremenko
Institution:(1) Nizhni Novgorod State Medical Academy, pl. Minina 10/1, Nizhni Novgorod, 603005, Russia
Abstract:The effect of ozonated saline on proteolytic enzymes (trypsin, chymotrypsin, elastase, kallikrein, leucine aminopeptidase), inhibitors of proteolysis and lipid peroxidation (LPO) has been investigated. Injection of ozonated saline caused marked response of the proteolytic system. Low ozone doses did not cause activation of proteolytic enzymes, whereas high doses activated proteases, decreased the level of inhibitors of proteolysis (α1-antitrypsin and α2-macroglobulin) and stimulated accumulation of LPO products. Thus, analyses of proteolytic activity can be used as an indicator of effectiveness and safety of ozone therapy and other treatment programs.
Keywords:ozone  trypsin  kallikrein  elastasa  pancreas
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