L-Tenuazonic Acid,a New Inhibitor of Paenibacillus Larvae |
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Authors: | Gallardo Gabriela L Peña Nora I Chacana Pablo Terzolo Horacio R Cabrera Gabriela M |
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Institution: | (1) Depto de Química Orgánica, FCEyN, UBA, Ciudad Universitaria, Pab. II (1428), Buenos Aires, Argentina;(2) Depto de Biología, FCEyN, UNMdP, Mar del Plata, Argentina;(3) Lab. Bacteriología, Depto Prod. Animal, INTA EEA, Balcarce, Argentina |
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Abstract: | A search for bioactive compounds, inhibitors of Paenibacillus larvae, the causal agent of American foulbrood, a honeybees' disease, was carried on. Extracts of two fungal strains, Alternaria brassicicola and Alternaria raphani, isolated from pollen collected from beehives, exhibited a specific inhibitory activity against this bacterium. From these
extracts and by means of chromatographic steps and bioassay-guided fractionation, three tetramic acids were isolated. The
compounds were identified by spectroscopic methods and the absolute stereochemistry was chemically determined. L-Tenuazonic
acid was shown to be responsible for the antibiotic activity. This compound showed a MIC of 32 μg/ml, comparable with that of oxytetracycline, an antibiotic currently used for the prevention of American foulbrood.
This revised version was published online in July 2006 with corrections to the Cover Date. |
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Keywords: | Alternaria brassicicola Alternaria raphani American foulbrood L-Tenuazonic acid Paenibacillus larvae tetramic acids |
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