Nanomaterials for cancer therapy and imaging |
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Authors: | Ki Hyun Bae Hyun Jung Chung Tae Gwan Park |
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Institution: | 1.Department of Biological Sciences and Graduate School of Nanoscience and Technology,Korea Advanced Institute of Science and Technology,Daejeon,Korea |
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Abstract: | A variety of organic and inorganic nanomaterials with dimensions below several hundred nanometers are recently emerging as
promising tools for cancer therapeutic and diagnostic applications due to their unique characteristics of passive tumor targeting.
A wide range of nanomedicine platforms such as polymeric micelles, liposomes, dendrimers, and polymeric nanoparticles have
been extensively explored for targeted delivery of anti-cancer agents, because they can accumulate in the solid tumor site
via leaky tumor vascular structures, thereby selectively delivering therapeutic payloads into the desired tumor tissue. In
recent years, nanoscale delivery vehicles for small interfering RNA (siRNA) have been also developed as effective therapeutic
approaches to treat cancer. Furthermore, rationally designed multi-functional surface modification of these nanomaterials
with cancer targeting moieties, protective polymers, and imaging agents can lead to fabrication versatile theragnostic nanosystems
that allow simultaneous cancer therapy and diagnosis. This review highlights the current state and future prospects of diverse
biomedical nanomaterials for cancer therapy and imaging. |
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Keywords: | cancer therapy drug delivery system imaging nanoparticles small interfering RNA |
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