| 三种药用植物内生菌的分离及其抗肿瘤活性菌株的筛选 |
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| 引用本文： | 陈传文,孙前光,朱军,吴晓鹏,黄惠琴,鲍时翔. 三种药用植物内生菌的分离及其抗肿瘤活性菌株的筛选[J]. 微生物学通报, 2010, 37(10): 1462-1466 |
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| 作者姓名： | 陈传文 孙前光 朱军 吴晓鹏 黄惠琴 鲍时翔 |
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| 作者单位： | 1. 中国热带农业科学院热带生物技术研究所,海南海口,571101;海南大学农学院,海南海口,570228
2. 中国热带农业科学院热带生物技术研究所,海南海口,571101 |
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| 基金项目： | 中央级公益性科研院所基金项目(No. ITBBZD2007-5-1) |
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| 摘 要： | 对204株分离自长春花、海南粗榧和见血封喉的内生菌进行了抗肿瘤活性筛选。结果显示,有19株内生菌的发酵液至少对一种指示瘤株具有细胞毒活性,其中4株菌的发酵液对S180的抑制率较强,均在70%以上。研究表明菌株PA09006和PA09009发酵液中的抗肿瘤活性物质,具有一定的酸碱耐受性,并且对温度和紫外线具有一定的稳定性。
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| 关 键 词： | 长春花 海南粗榧 见血封喉 内生菌 细胞毒活性 |
Isolation and Screening for Endophyte with Antitumor Activities from Three Medicinal Plants |
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| CHEN Chuan-Wen,SUN Qian-Guang,ZHU Jun,WU Xiao-Peng,HUANG Hui-Qin and BAO Shi-Xiang. Isolation and Screening for Endophyte with Antitumor Activities from Three Medicinal Plants[J]. Microbiology China, 2010, 37(10): 1462-1466 |
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| Authors: | CHEN Chuan-Wen SUN Qian-Guang ZHU Jun WU Xiao-Peng HUANG Hui-Qin BAO Shi-Xiang |
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| Affiliation: | 1. Institute of Tropical Bioscience and Biotechnology, CATAS, Haikou, Hainan 571101, China; 2. College of Agriculture, Hainan University, Haikou, Hainan 570228, China;1. Institute of Tropical Bioscience and Biotechnology, CATAS, Haikou, Hainan 571101, China;1. Institute of Tropical Bioscience and Biotechnology, CATAS, Haikou, Hainan 571101, China;1. Institute of Tropical Bioscience and Biotechnology, CATAS, Haikou, Hainan 571101, China;1. Institute of Tropical Bioscience and Biotechnology, CATAS, Haikou, Hainan 571101, China;1. Institute of Tropical Bioscience and Biotechnology, CATAS, Haikou, Hainan 571101, China |
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| Abstract: | Two hundred and four endophytes isolated from Catharanthus roseus, Cephalotaxus hainanensis and Antiaris toxicaria were screened for antitumor activities. The results showed that broth of 19 strains presented cytotoxic activities to at least one of the tested tumor cells, four of them exhibited strong antitumor activity against S180, were above 70%. Studies have shown that broth in the antitumor active substances of strains PA09006 and PA09009, confer a certain to pH value and ultraviolet. |
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| Keywords: | Catharanthus roseu Cephalotaxus hainanensis Antiaris toxicaria Endophyte Cytotoxic activity |
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