Regio- and Stereo-selective Hydroxylation of Abietic Acid Derivatives by Mucor circinelloides and Mortierella isabellina |
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| Authors: | Koichi Mitsukura Takeshi Imoto Hirokazu Nagaoka Toyokazu Yoshida Toru Nagasawa |
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| Institution: | (1) Department of Biomolecular Science, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan |
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| Abstract: | Mucor circinelloides and Mortierella isabellina hydroxylated dehydroabietic acid (DehA). DehA was converted regio- and stereo-selectively by whole cells of Mr. circinelloides to give 2α-hydroxydehydroabietic acid in a 75% molar conversion yield (11 mM from 14.7 mM DehA) after 72 h in the cultivation medium containing 3% (v/v) Tween 80. With cells of Ma. isabellina, under the same conditions, 20.5 mM (6.5 g l−1) 2–hydroxydehydroabietic acid (α/β=81/19) was formed from 26.4 mM DehA. |
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| Keywords: | abietic acid derivatives microbial hydroxylation regio-selective stereo-selective |
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