Deficiency of lipoprotein lipase in neurons modifies the regulation of energy balance and leads to obesity期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Deficiency of lipoprotein lipase in neurons modifies the regulation of energy balance and leads to obesity

Authors:	Wang Hong Astarita Giuseppe Taussig Matthew D Bharadwaj Kalyani G DiPatrizio Nicholas V Nave Klaus-Armin Piomelli Daniele Goldberg Ira J Eckel Robert H

Institution:	Division of Endocrinology, Metabolism, and Diabetes, Department of Medicine, University of Colorado, Denver Anschutz Medical Campus, Aurora, CO 80045, USA.

Abstract:	Download : Download high-res image (254KB) Download : Download full-size image Highlights? Mice with lipoprotein lipase deficiency in neurons (NEXLPL) are obese ? NEXLPL mice develop obesity by modifying both food intake and energy expenditure ? NEXLPL mice have increases in hypothalamic AgRP/NPY gene expression before obesity ? NEXLPL mice demonstrate deficiencies in n-3 fatty acids in the hypothalamus

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